Stem cells are often called MASTER CELLS, and form the foundation for your entire body as building blocks for the blood, immune system and organ tissue. They have the ability to REPLICATE and REGENERATE themselves and has the ability then to DIFFERENTIATE into any kind of specialised cell in the body.
A stem cell can differentiate into any one of 220 different specialised cells in the body.
There are different kinds of stem cells that are found in the human body throughout the course of life. They vary in exactly what they can and cannot do, but fall within two main categories.
|Multipontent /adult||Can only differentiate into certain types of specialised cells.|
|Work as a repair system in maintaining the specific tissues|
|Found in e.g. blood stem cells forming red blood cells, white blood cells and platelets, mesenchymal stem cells forming only certain tissue cells etc.|
|Cord blood and tissue stem cells can be found in a newborn baby’s umbilical cord and are classified as adult stem cells. These stem cells are practically brand new and have a greater capacity to grow, multiply and differentiate meaning that they have enhanced regenerative abilities in comparison to other sources.|
|Pluripotent||Can differentiate into all specialised cells in the body.|
|Embryonic stem cells.||Induced pluripotent stem cells.|
|Controversial and not part of our business or education process.||Generated from specialised cells by using a technique called “reprogramming”. This ground breaking work was awarded the Nobel Prize in Physiology or Medicine in 2012 and is in the very early stages of research.|
New York, 1956 – American doctor E. Donnall Thomas did the first successful bone marrow transplant to cure leukemia.
Blood stem cell transplantation, using stem blood cells from sources such as bone marrow, has been performed for MORE THAN 50 YEARS, with more than 1 MILLION BLOOD STEM CELL TRANSPLANTS across the world playing an important role in the treatment of bone marrow failures, blood cancers, blood disorders, metabolic diseases, immune deficiencies and autoimmune diseases.
Why may a bone marrow transplant (also called a blood stem cell transplant) be needed?
To treat and/or cure certain types of blood related disease, for example to:
- replace diseased bone marrow with healthy bone marrow to treat/cure patients with e.g. blood cancer
- replace non-functioning bone marrow with healthy functioning bone marrow in patients with e.g. acquired bone marrow failure.
- regenerate a healthy immune system in patients with e.g. immune deficiencies, autoimmune disease
- replace bone marrow with genetically healthy functioning bone marrow in patients with inherited blood related diseases.
What are your chances of finding a blood stem cell donor in SA?
1 in a 100 000
Depending in a person’s tissue type, the chance of finding a bone marrow donor may be less than 1 in a 100 000
healthy donors registered on the SABMR
THERE IS NO PUBLIC UMBILICAL CORD BLOOD BANK IN SOUTH AFRICA.
Banked umbilical cord blood can potentially provide easier access to a stem cell transplant
Blood stem cells used in transplants can be collected from:
- bone marrow
- circulating blood
- umbilical cord blood
The chances of needing a stem cell transplant in a lifetime of 70 years
A newborn’s stem cells are young and flexible, which means they have better regenerative abilities.
Umbilical cord stem cells have greater therapeutic potential than bone marrow stem cells. They are young and active in comparison with stem cells from other sources – ‘a maximum of nine months old’ – which means that they can differentiate faster.
Cord blood is collected in advance, tested, cryopreserved and stored – ready to use when needed.
Because your baby’s stem cells were collected at birth, they are ready to use if necessary.
Unlike bone marrow, there is no need to take time to locate a possible donor and then determine whether he or she is still willing and able to donate if required for a sibling transplant.
Cord blood transplants do not always require a perfect match.
Studies have shown that cord blood transplants can be performed in cases where the donor and the recipient are only partially matched. In contrast, bone marrow grafts require a perfect degree match in most cases. Because partially matched cord blood transplants can be performed, cord blood potentially increases a patient’s chance to find a suitable donor.
Cord blood transplants are associated with a lower incidence of graft-versus-host-disease (GVHD) in allogeneic transplants (e.g. between siblings). The immune cells in cord blood are less likely to attack the recipient’s own tissues and cause the transplant-related complication of GVHD.
THERE ARE NEARLY 8 TIMES AS MANY BLOOD STEM CELLS IN CORD BLOOD IN COMPARISON TO BONE MARROW.
Collecting stem cells from umbilical cord blood is QUICK, PAINLESS and NON-INVASIVE – posing no medical risk to mother or baby.
Once a baby is born, the umbilical cord is clamped and cut as per normal in any birth. It is only after this that the blood and tissue are collected from the umbilical cord for stem cell processing, so cord blood and tissue collection poses no medical risk to the newborn baby or mother.
The umbilical cord stem cells are collected from what is usually discarded as medical waste after the birth of a baby.
THE GOAL OF A BONE MARROW TRANSPLANT / BLOOD STEM CELL TRANSPLANT IS TO TREAT AND/OR CURE CERTAIN TYPES OF BLOOD RELATED DISEASES.
Banked umbilical cord blood can potentially provide easier access to a stem cell transplant.
Studies have shown that cord blood transplants can be performed in cases where the donor and the recipient are only partially matched, depending, for example, on the number of stem cells in the collection. In contrast, bone marrow transplants require a perfect match in most cases
Your baby’s cord blood stem cells will always be:
AT LEAST A HALF MATCH
using your own stem cells
using stem cells from an identical twin
using stem cells from biological parents
25% CHANCE OF BEING A PERFECT MATCH FOR
1:100 000 CHANCE OF BEING A PERFECT MATCH
using your sibling’s stem cells
using an unrelated donor’s stem cells (recruited through the South African Bone Marrow Registry)
The good news is that with umbilical cord blood stem cells, you don’t always need a perfect match.
This increases your chances of finding a matching donor.
Stem cell therapies, bioprinting and other technologies are transforming the future of healthcare
Replace dead or diseased cells
- Stem cells are used to replace dead or diseased cells e.g. blood stem cell transplant.
Regenerate tissue and organs
- Stem cells are used in clinical trials to regenerate tissues and organs.
Bioprint tissues or organs
- Stem cells are being used to 3D print tissues and organs.
Enhance the body’s regenerative potential
- Scientists are studying ways to use the body’s intrinsic regenerative ability to initiate and enhance repair.
What will future results be for cord blood and tissue stem cell therapy?
As medical science continues its research into stem cells and their flexibility, the list of possible treatments grows. Recent research into the stem cells found in cord tissue has shown potential in regenerative medicine. These cells, also known as mesenchymal stem cells (MSC), can transform into many types of cells and tissues, including organs, muscles, skin and bone. Trials are underway that look into using stem cell therapies with MSC to potentially treat autism, cerebral palsy, diabetes, spinal injuries and many others. For up to date information about new developments in stem cell research, visit www.ecsbio.com
Diseases Currently Treatable
- Acute Lymphoblastic Leukaemia (ALL)
- Acute Myeloid Leukaemia (AML)
- Chronic Myeloid Leukaemia (CML)
- Myelodysplastic Syndrome (MDS)
- Multiple Myeloma
- Hodgkin’s Lymphoma
- Non-Hodgkin’s Lymphoma
- Bone marrow failure syndromes
- Severe Aplastic Anaemia, Unspecified
- Fanconi Anaemia
- Sickle Cell Disease
- Severe Combined Immune
- Deficiency (SCID)
- Wiskott-Aldrich Syndrome
INHERITED METABOLIC DISORDERS
- Hurler Disease (MPS type IH)
- Krabbe Disease
- Systemic Lupus (SLE)
Therapies in Clinical Trials
with cord blood
- Autism (Phase 2)
- Cerebral Palsy (Phase 2)
- Hearing Loss (acquired sensori-neural) (Phase 2)
- Hypoxic Ischemic Encephalopathy (HIE) (Phase 1)
- Spinal Cord Injury (Phase 2)
- Crohn’s Disease (Phase 3)
- Diabetes, Type 1 (Phase 2)
- Graft-versus-Host Disease (GvHD) (Phase 3)
- Kidney plus stem cell transplant (Phase 2)
- Systemic Lupus (SLE) (Phase 2)
- Multiple Sclerosis (Phase 1)
- Rheumatoid Arthritis (Phase 2)
- Scleroderma (Phase 2)
- Critical Limb Ischemia (Phase 3)
- Ischemic Stroke (Phase 2 placenta) (Phase 3)
- Myocardial Infarction (Phase 3)
- Cardiomyopathy (Phase 3)
Speak to your doctor or midwife about the importance of collecting enough cord blood.
COLLECTING CORD BLOOD IS A SAFE, EASY AND PAINLESS PROCEDURE THAT CAN SUCCESSFULLY BE COMBINED WITH DELAYED CORD CLAMPING.
The placenta and umbilical cord hold enough blood to allow delaying the cord clamping by 1 – 3 minutes (the recommended time given by the World Health Organization) and still have enough for a successful cord blood collection. Chances of a successful collection will naturally increase by combing in+ex utero collection.
The most important consideration is collecting enough cord blood because in general, there is a correlation between the volume of cord blood collected and the number of stem cells in a collection.
Combining in- and ex-utero collection is the best-practice solution to collect enough cord blood. Combining these methods is particularly useful when the in-utero volume is low, for example due to delayed cord clamping.
For a collection to be potentially successful, a minimum collection of 80ml of cord blood is recommended.
Stage 2 Labour
Cord blood collection takes place after birth and only once the umbilical cord has been clamped and cut. It is a painless procedure that poses no risk to mother or baby.
With in-utero collection, the cord blood is collected immediately after the umbilical cord has been cut and before the expulsion of the placenta. This extraction mode requires about 10 minutes and is faster because uterine contractions allows cord blood to flow more easily.
Ex-utero collection takes place after the expulsion of the placenta and takes about 25 minutes to complete.
Other benefits of combining these collection methods include:
- There is a significantly higher total nucleated cell counts (TNC) in the in- & ex-utero collection vs. inutero collection.
- There is no statistically significant difference in the microbial contamination rate in in-utero vs. in- & exutero collection, however it is lower in the ex-utero collection compared to either the in-utero or ex utero collections.
- In- and-ex utero collection of umbilical cord blood for banking is safe and results in significantly higher TNCs than either technique alone.
Blood stem cell transplants have been performed for more than 50 YEARS and have been used to treat or cure with more than 80 potentially life threatening blood related diseases like leukaemia, lymphoma, bone marrow failures.
Blood stem cells used in transplants can be collected from:
- Bone marrow
- Circulating blood
- Umbilical cord blood
Cord blood stem cells are also currently used to treat (within clinical trials):
1. Cerebral palsy
Specialists involved, Joanne Kurtzbery & Colleen Delaney are optimistic and started the Phase II trials early this year.
Within the Cryo-Save Group internationally, there have been 18 stem cell release to date – to centres such as Duke University North Carolina, USA, Kliniek Pediatrische Hematologie en Oncologie Frankfurt, Germany and Kinderspital Zurich, Switzerland.
We also had one South African release, which was for diagnostic genetic testing for acute lymphocytic leukaemia.
This confirms that Cryo-Save South Africa laboratory aligns with international standards give you an indication of the standards of our cord
have been for autologous (own stem cells) & sibling transplants
have been for clinical trails for cerebral palsy
National Cord Blood Program, http://www.nationalcordbloodprogram.org/patients/ncbp_diseases.pdf